The Mentor character was loosely based upon Uncle Marvel, who in concurrent 1970s issues of the Shazam! comic book began sporting a mustache to resemble Les Tremayne, the actor who appeared as "Mentor" on the Shazam! TV show. A live-action Shazam! television series, which aired on CBS Saturday mornings from 1974 to 1976, featured Captain Marvel and his young alter-ego Billy Batson, accompanied by an old man known as Mentor. Uncle Dudley was more prominently featured in the two-issue Convergence tie-in Convergence: Shazam! in 2015, as well as a brief cameo in the "Thunderworld" issue - issue #4 - of Grant Morrison's miniseries The Multiversity. Dudley continued to appear in The Power of Shazam! for the duration of the series as a recurring supporting character, often paired with Tawky Tawny, an anthropomorphic tiger friend of Captain Marvel's who becomes Dudley's roommate.įollowing the cancellation of The Power of Shazam! in 1999, "Uncle" Dudley virtually disappeared from DC Comics publications, save for a short cameo in 52 #16 at the wedding of Marvel Family related characters Black Adam and Isis and two brief cameos in Jerry Ordway-illustrated issues of Justice Society of America in 2009 (Vol. This revelation leads Dudley to be involved in a number of Marvel Family adventures, including one story ( The Power of Shazam! #11 and #12) in which Dudley temporarily gains superpowers (and the "Uncle Marvel" costume of the original version of the character) thanks to Ibis the Invincible. Dudley is the janitor at Billy Batson's school, who looks out for the homeless boy and inadvertently learns that Billy is also the alter ego of Captain Marvel. In Roy Thomas and Tom Mandrake's four-issue 1987 miniseries Shazam!: The New Beginning, the character became Dudley Batson, an actual blood uncle of young Billy Batson, Captain Marvel's alter-ego.Ī second revamped version of Uncle Marvel was introduced in Jerry Ordway's Power of Shazam! graphic novel in 1994 and a resulting ongoing comic book series of the same name, rendering Thomas and Mandrake's version non- canonical. After forty years of appearing in the Marvel Family comics, Uncle Dudley was revamped in 1987 along with the rest of the Shazam! franchise. He returned to the Marvel Family comics when DC Comics began publishing new stories and reprints under the title Shazam! in 1973, he was put into suspended animation, along with many other Fawcett characters, explained as an attack gone wrong by the Sivana family. Uncle Marvel continued to appear in the Marvel Family stories through 1948, at which time the character was quietly dropped. The criminals attempt to force Dudley to write a ransom note, but midnight arrives and Mary transforms into Mary Marvel to stop them. He then sends two men to rob the office, not knowing they are actual criminals who kidnap Mary and try to hold her for ransom. In Mary Marvel #7, after Mary stops some thugs, Dudley makes Mary promise not to turn into Mary Marvel until midnight, to show that she is helpless without Mary Marvel. Though mostly played as comic relief, Dudley plays a key role in Marvel Family #1 as he tricks the rogue Marvel Black Adam (debuting in that story) into saying the magic word "Shazam" and reverting to his mortal self. When asked to make use of his supposed superpowers, Dudley would always complain that his " shazambago" was acting up and was interfering with his powers, though the Marvels always knew better. The Marvels, possessing the wisdom of Solomon, saw through Dudley's machinations, but since he was, in their opinion such a "lovable old fraud", they allowed Dudley to join the team as their manager Uncle Marvel and humored his pretense of having Marvel powers. Claiming to be the uncle of Mary Batson, Mary Marvel's teenage alter-ego, from California, Dudley attempted to con his way into the Marvel Family. She had accidentally dropped the ledger, and Dudley read it, learning her secret. He found Mary Batson's good deed ledger, which she kept to record her good deeds. Fictional character biography Īn old, rotund man named Dudley, Uncle Marvel did not have any real superpowers. Dudley) is a fictional comic book character, originally created for Fawcett Comics, and today owned by DC Comics, who appears in stories about the Marvel Family team of superheroes.Ĭreated by Otto Binder and Marc Swayze, Uncle Marvel was created primarily as a supporting character of Mary Marvel and first appeared in Wow Comics #18 in October 1943. Uncle Marvel (fourth from left) standing with the Marvel Family before the Wizard Shazam (right) on the cover of The Marvel Family #1.
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For your comfort, we have summarized their offer, highlighting crucial aspects like prices and the number of photos you receive. Would you rather visit a physical location? Here are the most popular places to get passport photos in the United States. If you hesitate about whether something is acceptable, you can always rely on our expert’s feedback! Where to get a passport photo? The exceptions include medical or religious reasons for wearing them.Įnsure your passport photo reflects your natural, current appearance. Glasses and headgear, in general, are forbidden.Jewelry is acceptable-just make it simple. Give up on anything that can cause reflections or shadows in your passport photo. Everything, including your hair, must fit into the 2x2 photo. Just be careful about your hair covering any part of your face or your hairstyle going beyond the picture’s frame. You have complete freedom as to your hairstyle.Also, avoid white clothes-you don’t want to blend with the background, after all! You should look as natural as possible in your passport photo. Here are some tips that will help you prepare perfect passport pictures: While the US Department of State’s clothing guidelines are quite relaxed, there are some aspects you must pay attention to when choosing clothes and accessories for your passport photo. But what about the passport photo dress code? Does it even exist? Whether you’re looking to change the mood of your image with filters, add design assets like text, shapes and other graphics, or even convert your image into an animation, Adobe Express has everything you need for all your content-making needs.Straight poses and neutral facial expressions are one thing. It also comes with an array of other powerful image-editing and content-creation tools that help bring any idea to life. 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However, through exploratory analyzes in subgroups with higher expression of PD-L1, it was observed that the effect of treatment with pembrolizumab increased as the enrichment of PD-L1 increased, and that the antitumor activity of pembrolizumab is better in the scenario of first-line treatment.īased on the rationale that immunological checkpoint inhibition can enhance endogenous antitumor immunity following increased release of tumor-specific antigens with chemotherapy, the phase 3 study KEYNOTE-355 (NCT02819518) was designed. In this study, pembrolizumab did not improve the overall survival of patients in the second- or third-line setting compared with chemotherapy. In this study, pembrolizumab demonstrated the same safety profile and showed durable antitumor activity as a first-line therapy for this profile of patients.īecause of these promising results, the randomized, open-label, phase III study KEYNOTE-119 (NCT02555657) was designed to evaluate the use of pembrolizumab versus chemotherapy in participants with metastatic TNBC previously treated. Cohort A included 170 patients with metastatic TNBC previously treated, regardless of PD-L1 expression and cohort B evaluated the use of pembrolizumab as monotherapy in 84 patients with metastatic TNBC previously untreated PD-L1 positive. The phase II study KEYNOTE-086 (NCT02447003) evaluated pembrolizumab monotherapy in two cohorts of patients with metastatic TNBC. In the phase Ib study KEYNOTE-012 (NCT02447003), pembrolizumab treatment showed durable antitumor activity and manageable safety in a subset of patients with TNBC metastatic (n=32) pre-treated and has PD-L1 positive. In this context, pembrolizumab becomes a drug with high therapeutic potential for patients with triple negative breast cancer. In the case of breast cancer, although PD-L1 is rarely expressed in normal breast tissue, it can be expressed in some breast cancer cells and surrounding immune cells, where it can mediate inhibition of tumor-infiltrating lymphocytes (TILs). Therefore, tumors may express programmed death ligands 1 and 2 (PD-L1 and PD-L2, respectively) as a mechanism of adaptation to the immune system. PD-1 is expressed on the surface of activated T cells, where it interacts with its ligands to attenuate signaling – which results in downregulation of T cell proliferation, inhibiting the antitumor immune response. Programmed death pathway 1 (PD-1) represents an immunological checkpoint used by tumor cells to avoid attack by tumor-targeted T cells. It has been investigated alone and in combination with other antitumors therapies. This drug has demonstrated robust antitumor activity and a favorable safety profile in several types of tumors, which has led to regulatory approval by ANVISA in at least 20 different indications. Pembrolizumab is a highly selective, humanized, PD-1-targeted monoclonal antibody. In that regard, triple negative breast cancer (TNBC) differs from other types of breast cancer in that it grows and spreads faster, in addition to having limited treatment options and worse prognosis. The group of patients HER2+ is the group referred triple-negative breast cancer (HR-/HER-), represent respectively about 20% and 15% of patients with this type of cancer. The group of patients with the disease that expresses hormone receptors (HR+/HER2-) is the most prevalent – represents approximately 70% of cases. The diseases are considered heterogenous and its molecular subtype differ in genomic complexity, major genetic alterations, and clinical prognosis. Annually in Brazil the breast cancer represents approximately 28% of new cases of cancer – being the second type of neoplasm more incident among women. Here we approach the main studies that led to these approvals. Pembrolizumab in combination with chemotherapy is already FDA-approved for the treatment of patients with triple-negative breast cancer – in the setting of early or metastatic diseases. Ninja Gaiden 2 on the consoles), but it does offer more than a few hours of fun gameplay, and the addictive and original bonus levels are well worth playing for. Overall, Shinobi isn't as varied or atmospheric as the best ninja platformers (e.g. Although the level bosses are definitely too simple to defeat, some of the later levels will require precise timing and inhuman reflexes. Shinobi is not a hard game, but it is not too easy either. If one of them gets close enough, the stage ends and you don't receive any ninja magic. You must throw shurikens at enemy ninjas in an attempt to keep them from reaching the front of the screen. You view a close platform and a distant one from a first-person perspective. As they are rescued, Jo-Musashi will have his life meter replenished.īonus stages, which become available at the end of a level if enough hostages are rescued, are the most difficult part of the game but also arguably the most fun. Shinobi is an umbrella term for the central character in a series of video games developed by SEGA commonly referred to as the Shinobi series. Hostages are spread out through each level. Shinobi (PS2 version) is now available on North America PSN Weve got a few more codes to pass out in 15 minutes - stay tuned 11:00 PM Aug 14. There is no time limit in the game, so you can take your time to eliminate one enemy at a time. One key for attacking, one for jumping, another for ninja magic, etc. Sega revives its classic ninja franchise on the PlayStation 2. The controls in the game are easy to use. Sega releases new screens from Overwork's PS2 game. The PC version of Shinobi has very poor graphics compared to the original arcade game (duh) and suffers from worse playability, but it's a decent action game for PC standards of that time. You slip into the role of Jo-Musashi, a modern ninja who's off to rescue hostages and to kill everything on screen with your shuriken and sword. It was released for the PlayStation 2 console on November 10, 2002, in North America December 5 in Japan and May 15, 2003, in Europe. Shinobi is a 3D action videogame that was developed by Overworks and published by Sega as part of the Shinobi series. SEGA's popular side-scrolling arcade game converted to the IBM-PC. Shinobi is a 3D action-adventure video game developed by Overworks and published by Sega as part of the Shinobi series. Which? says mortgages with a higher loan-to-value level are more likely to be offered without a fee in a bid to attract first-time-buyers with less money to spare.Īnalysts at the consumer champion have compiled this table which shows how much someone would pay over two years, on a £200,000 mortgage fixed to a 25-year term, in different scenarios:Īn expert adviser on retail theft has cautioned supermarkets against creating "threatening and intimidating" aisles full of barriers, security tags and dummy products. The average fee tends to hover around the £999 mark- and high fees can sometimes disguise attractive rates, so make sure you go through all the details with your mortgage broker. The effect of interest rates on mortgage costs is a significant issue on the minds of first-time buyers and those approaching the end of their fix.īut people looking to find a new deal also have to consider the possibility that their policy may come with an upfront fee - a less-discussed aspect of the mortgage-hunting process.Īnalysis by consumer champion Which? found that six in 10 fixed-rate and tracker mortgages on the market now come with product fees - with the highest charge sitting at a whopping £3,999 set by Halifax. "Based on the £1.81trn that Brits have in savings accounts, it means the nation's savings could have collectively lost as much as £113bn over the past year in real terms." The average saver with £1,000 in an easy-access account will now find their cash is only worth £938 in today's money, Ms Suter added. "Although interest rates have risen considerably over the past year and a half, savers still lost money in real terms thanks to double-digit inflation for much of that period," she said. The platform's head of personal finance Laura Suter says savers are "still being pummelled" despite a slight fall in inflation, as they put up with lower returns on their savings. Packages going to certain places (including Alaska, Hawaii, and offshore destinations), or containing hazardous materials or live animals may receive slower service.The rising cost of living has left many of us feeling the pinch in our day to day lives - but also when it comes to preparing for the future.Īnalysis by investment platform AJ Bell suggests that as much as £113bn may have been wiped off the value of the nation's savings in real terms over the past year as a result of rising inflation. In most cases, the expected delivery date that is printed on your receipt or provided at checkout will reflect a delivery time of 1, 2, or 3 days based on origin, destination, and Post Office ™ acceptance time. For additional information, visit the Postage Calculator. Scheduled delivery date and time depends on origin, destination, and Post Office ™ acceptance time. See the International Mail Manual for availability and limitations of coverage. Purchased insurance replaces ordinary indemnity coverage. Not available with Flat Rate envelopes and small Flat Rate boxes or when shipping to certain destinations. For details regarding claim exclusions, see Sections 609.4.3 (Non-payable Claims), 609 (Filing Indemnity Claims for Loss or Damage), and 503.4 (Insured Mail) of the Domestic Mail Manual. Available only with certain products and to certain domestic destinations. For details on free Package Pickup, go to Schedule a Pickup. Family Involvement Family Involvement Resources Read! 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Brown Bear Brown Bear I See Shapes The Pledge of Allegiance Chicka Chicka Boom Boom Mouse Mess Ten Red Apples We're Going on a Leaf Hunt Patty's Pumpkin Patch The Very Busy Spider Goodnight Moon The Pilgrims' First Thanksgiving Hattie and the Fox The Little Red Hen The Gingerbread Man The Mitten The Three Bears Three Billy Goats Gruff Three Little Pigs Who Took the Cookies Mary Had a Little Lamb The Enormous Kinder Garden It Started as an Egg Rain I Like Bugs Caps for Sale Little Engine that Could.Phonics Booklets Word Families CVC Silent e.Sight Word Booklets Intro to Sight Words Fall Sight Word Booklets Winter Sight Word Booklets Spring & Summer Sight Word Booklets.Literacy Literacy Resources ABCs and Names ABCs and Rhyme ABC Centers Copywork Guided Reading Morning Message Printable Booklets Shared Reading Show and Tell Small Groups Spelling Student Made Books Writing Notebooks Writing Workshop.Kindergarten Prep for K Themes Curriculum Assessment Room Arrangement Developmental Centers Schedules. Pre-K Joyful Heart Character Overview Planning for JH Character Activities for JH Character Weeks 1-4 Weeks 5-8 Weeks 9-12 Weeks 13-16 Weeks 17-20 Weeks 21-24 Weeks 25-28 Weeks 29-32 Weeks 33-36 Weeks 37-38.Preschool Bible & Rhyme Overview Time for Bible and Rhyme Activities for Bible & Rhyme Weeks 1-3 Weeks 4-6 Weeks 7-9 Weeks 10-12 Weeks 13-15 Week 16 Weeks 17-18 Weeks 19-20 Weeks 21-23 Weeks 24-25 Weeks 26-27 Week 28.Toddlers Joyful Learning Overview Activities For Joyful Learning August September October November December January February March April May June July.Bible Basics Bible Truths Bible Reading. The Pfizer-BioNTech and Moderna vaccines proved to be safe and powerfully protective in clinical trials and were speedily authorized for use. In the trials in adults in 2020, vaccine manufacturers made best guesses at the right dose and opted for short intervals between the shots to protect people as quickly as possible during the initial surge. Recent studies suggest that the problem is not so much the vaccine as the dose. James Campbell, a physician at the University of Maryland School of Medicine and a member of the American Academy of Pediatrics committee on infectious diseases.Īmong his pediatric patients who were sick enough to need a mechanical ventilator or die, “every single one of them was unvaccinated,” Dr. That trend is particularly clear at hospitals, said Dr. The vaccines are continuing to prevent severe disease and death, even with the Omicron variant. The country may still see a surge in the fall or winter, and the best protection for children will be to have had at least two shots before then, she said. “But in the near term, it’s important for parents to still vaccinate children.” “We should be disappointed with the data - we wish it could be better,” said Luciana Borio, a former acting chief scientist at the Food and Drug Administration. And by now, as much as 95 percent of the country has some degree of protection from the virus because of vaccines or prior infection, according to recent data from the C.D.C.Įxperts worry that the most recent findings have made it even more challenging to persuade some parents to immunize their children. Those percentages are even lower in rural areas of the United States.Ĭhildren are less likely to experience illness, so the balance of risk and benefit was never the same as for adults. More than half of adolescents 12 to 17 are fully vaccinated, but only about 12 percent have received a booster dose. The results, if positive, should lead to a new round of regulatory review, perhaps as early as April, that may well allow vaccinations for tens of millions of youngsters.īut those findings will arrive as the Omicron variant fades in the United States, complicating parental decisions about whether to vaccinate children.įewer than one in four children aged 5 to 11 are now fully vaccinated. Both Pfizer and Moderna plan to report results from trials of their vaccines in young children. “I’ve come to the point that all I can do is what I think is right for my family.”įortunately, the coming weeks should bring some clarity. “The part that’s confusing is like there’s no longer any clear, right answer,” said Anne Gonzalez, a 41-year-old mother of two who manages volunteers for a large religious nonprofit in St. Who could blame parents for feeling bewildered? But the agency has since said that 90 percent of Americans can safely stop wearing masks in public indoor spaces, even in schools with young children. The Centers for Disease Control and Prevention found that record numbers of children under 5 had been hospitalized during the Omicron surge, underscoring the need for vaccines for those children. Through it all, experts have continued to endorse vaccines, noting that while the Omicron variant may be able to penetrate immune defenses and infect people, the vaccines still prevent severe illness and death - and may do so for years. On Monday, citing these data, Florida’s surgeon general declared that healthy children need not be immunized, advice that Jen Psaki, the White House press secretary, called “deeply disturbing.” Soon after, scientists reported that the vaccine was only weakly protective against infection with the Omicron variant among children aged 5 to 11 and that it appeared to offer little defense against moderate Covid illness among adolescents aged 12 to 17. In early February, federal regulators announced that they would evaluate Pfizer-BioNTech’s coronavirus vaccine for the youngest children - only to scrap that plan 10 days later, citing doubts about the vaccine’s effectiveness in that age group. For American parents, particularly those with young children, the last couple of months have been dizzying and beyond frustrating. Now you have to watch this movie to know everything about what will happen next. Title: Tuck Jagadish Cast: Nani, Jagapathi Babu, Aishwarya Rajesh and others Director: Shiva Nirvana Rating: 2. Jagdish is then called the Divisional Revenue Officer (MRO) for that village with the support of the District Collector and begins to rectify all the work done by his brother. When he tries to talk her into sharing his share of wealth with other family members, he is stopped by his brother Bosu. Upon returning to the village, he is angry about being kept in the dark regarding property disputes, farm issues, etc. After the death of his father, Jagdish is also sent to the city for further studies and is not informed about his niece's marriage. Bosu also insults Adisha's second wife and her half-siblings when they ask for a share in the property, for which they are thrown out. He secretly strikes a deal with Virendra and gets his niece Chandra married to Virendra's brother, in return for a windmill project on the site of fields leased by Adisha to local farmers. When Adisha died of cardiac arrest, Bosu threatened the lawyer and made sure to draw up a will to grant her access to all family assets instead of her other siblings', contrary to her father's wishes. On one such occasion, Virendra's father dies in a quarrel and develops hatred towards Adisha's family. Bhudevipuram is notorious for its property disputes which are usually resolved by Adisha Naidu. He also hates the thought that his father has a soft corner for his daughters. However, Bosu secretly dislikes the other members of the family because he believes that as the first wife's first son, he is the sole rightful heir to his father's estate. After the death of his first wife, Adisha takes another wife and has children with her, all of whom are brought together as a joint family. They have two sons, Bosu Babu and Jagdish Naidu. Singers : Shreya Ghoshal, Kaala BhairavaĪdisha Naidu is the head of Bhudevipuram village.Singers : Armaan Malik, Harini Ivvaturi.Tuck Jagdish's cinematography is done by Prasad Murella and editing by Praveen Pudi. The soundtrack and background music of the film is composed by S Thaman and Gopi Sundar. Nani is seen in the lead role along with Ritu Varma, Aishwarya Rajesh and Jagapathi Babu in the star cast of Tuck Jagdish. The film is slated to release on Amazon Prime Video on 10 September 2021, coinciding with the festival of Vinayaka Chaviti. Tak Jagdish's theatrical release was postponed several times due to the COVID-19 pandemic, as a result of which the makers opted for a direct-to-streaming release. Tuck Jagadish is a Telugu language romantic family entertainer film written and directed by Ninnu Kori and Majili fame Shiva Nirvana and produced by Sahu Garapati and Harish Peddi under the banner of Shine Screen. There is no concrete information about whether Tuck Jagadish movie will be hit or flop. See more information about these two options below. Simply select your chosen bracelet size in the checkout, or alternatively speak with a member of our sales team who will be more than happy to arrange for your watch to be professionally sized before we deliver to your front door.Īlternatively, you can resize your bracelet yourself using our watch sizing tool, available to select in the checkout as a free gift with new watch purchases over £250. Let us take care of the sizing for you with our free and professional watch sizing service. Our simple to use watch sizing guide allows you to measure the size of your wrist from the comfort of your own home. 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